
- Oxygen atom of Hydroxyl group
- Weakly Basic (Due to lone-pairs.)
- Nucleophilic
- Hydrogen atom of Hydroxyl group
- Upon protonation it converts into a good leaving group (−H2O) from a poor one (−OH). Protonation also causes the carbon to be even more positive due to the higher electron withdrawing nature of (H2O+−). This makes it even more susceptible to nucleophilic attacks.
- At a high enough temperature and in absence of a good nucleophile, protonated alcohols are capable of undergoing E1 and E2 reactions. (Alcohol dehydrations.)